spatialbiology.co.uk

Region: England

  • Proteintech Europe (UK)

    Proteintech Europe provides antibodies, nanobodies and sample preparation kits that enable high-plex spatial proteomics projects across the UK. From its Manchester base, the team supports Akoya, Leica, Zeiss and Miltenyi users with ready-validated primary antibodies, ChromoTek recombinant VHH reagents, and antibody cleanup kits tailored for multiplex immunofluorescence and CODEX-style workflows.

    Highlights for spatial biologists:
    • 15,000+ antibodies with lot-specific validation in IHC, IF, flow and WB, including many clones optimised for FFPE panels
    • Nano-Secondaries and Fab blockers that minimise cross-reactivity in sequential staining protocols
    • Sample preparation buffers and antigen retrieval reagents tested on human, mouse and rat tissue sections

    Scientists can access technical support, lot reservation and QC documentation directly from the Proteintech Europe applications team in Manchester.

  • BioStatus Limited

    BioStatus Limited develops fluorescent dyes and buffers that improve nuclear visualisation and segmentation in high-plex imaging experiments. Based in Shepshed, Leicestershire, the company created the DRAQ5, DRAQ7 and CyTRAK Orange stains that are routinely incorporated into multiplex immunofluorescence, imaging mass cytometry and high-content screening protocols.

    Why researchers choose BioStatus products:
    • Ready-to-use nuclear counterstains compatible with live, fixed, FFPE and fresh frozen material
    • Reagents validated on Akoya, Leica, Zeiss and Yokogawa platforms to support single-cell segmentation and machine learning pipelines
    • ISO 13485–aligned manufacturing with batch-specific QC data and technical support from UK scientists

    Reagent packs ship worldwide from the UK HQ, with on-demand documentation to streamline spatial biology assay validation.

  • HistoCyte Laboratories

    HistoCyte Laboratories, part of the Atlas Antibodies group, manufactures analyte control materials that mimic tissue morphology for advanced IHC, ISH and multiplex immunofluorescence workflows. Operating from The Neon Building in Newcastle upon Tyne, the company engineers cell line–derived FFPE blocks and slides that provide same-slide positive and negative controls compatible with Leica, Ventana, Dako and Akoya staining platforms.

    Key products and services:
    • HER2, PD-L1, Ki-67, CD markers and bespoke target controls available as slides, scrolls or microarray cores
    • RNAscope / BaseScope-ready ISH controls to verify pre-analytical steps and spotting performance
    • Contract development of custom cell pellet lines, embedding and sectioning for biomarker assay validation programmes

    Laboratories adopt HistoCyte material to standardise quantitative imaging studies, improve lot-to-lot comparability and de-risk regulatory submissions.

  • HistologiX

    HistologiX is a GLP- and GCP-compliant tissue-based CRO headquartered inside BioCity Nottingham. The laboratory supports discovery through to late-stage clinical studies with end-to-end histology, multiplex immunostaining and digital pathology services. Core workflows cover multiplex IHC on Leica and Ventana platforms, RNAscope and BaseScope assays, image analysis in HALO and Visiopharm, and project management backed by CLIA-equivalent quality systems.

    Specialist programmes include:
    • Immuno-oncology biomarker development, immune cell phenotyping and TME mapping in FFPE cohorts
    • Cross-reactivity, toxicology and clinical trial sample management with rapid GLP reporting
    • Integration of pathologist scoring, AI quantification and regulatory documentation for submission-ready packages

    HistologiX works with pharma, biotech and diagnostic developers who need UK-based capacity for high-plex imaging and robust data packages.